I suppose I think all substances have teleology. For as Rob Koons and others have noted, a causal power always has the immediate effect of its exercise as its telos, and substances seem to always have causal powers.
But I think we can make a distinction between having the immediate effect of one’s causal power’s exercise as a telos and having a further telos for the causal power. In the latter case, the substance is exercising the causal power as a means to an end—whether intentionally or not. This seems to happen for all living things. It is not merely the telos of a bacterium to seek food, but to seek food in order to ingest it. Thus the seeking behavior is ordered in the bacterium’s teleology to the ingesting, and the ingesting is presumably ordered to further goods of bacterial functioning. On the other hand, when an electron repels another electron, the repulsion is the only telos the electron is pursuing. Of course, someone else (God or an electrical engineer, say) may have a further purpose for that repulsion, but that doesn’t seem to be the electron’s telos.
It seems that we have a difference between living and non-living substances, then: non-living substances have only immediate teleology, while living substances have both immediate and mediate teleology.
What about God? Well, initially it seems easy to say that, of course, God engages in means-end reasoning in creation all the time (e.g., making fruit for primates like us to eat), and hence has mediate teleology. But if mediate teleology is essential to life, it is troubling to identify God’s mediate teleology with anything done within creation, since God does not need to create.
Does God in himself have mediate teleology? One might see a positive answer within a certain version of western trinitarian theology: The Father generates the Son in part in order that the Holy Spirit might proceed through the Son. Thus there is a mediate teleology within God’s trinitarian being.
If this is the right answer, then we have a way in which the filioque is needed for God to be alive, and in which the Holy Spirit is life-giver—as per the Nicene Creed—not just to creatures, but to the blessed Trinity.
Perhaps there are other trinitarian things one can invoke besides the filioque. The Father generates the Son in order that the Son might love him back. But in any case, it is difficult to see how there can be essential mediate teleology in God apart from something like the doctrine of the Trinity.
Do we thus have another argument for the multiplicity of persons in God?
God is simple.
God does not have to create.
Life essentially involves mediate teleology.
God is essentially alive.
If God is essentially alive and simple and does not have to create, the only way for him to have essential mediate teleology requires a multiplicity of hypostases.
All that said, I am not 100% convinced that we should think of mediate teleology as an essential feature of life.