The ordinary sentence "There are four chairs in my office" is true (in its ordinary context). Furthermore, its being true tells us very little about fundamental ontology. Fundamental physical reality could be made out of a single field, a handful of fields, particles in three-dimensional space, particles in ten-dimensional space, a single vector in a Hilbert space, etc., and yet the sentence could be true.
An interesting consequence: Even if in fact physical reality is made out of particles in three-dimensional space, we should not analyze the sentence to mean that there are four disjoint pluralities of particles each arranged chairwise in my office. For if that were what the sentence meant, it would tell us about which of the fundamental physical ontologies is correct. Rather, the sentence is true because of a certain arrangement of particles (or fields or whatever).
If there is such a broad range of fundamental ontologies that "There are four chairs in my office" is compatible with, it seems that the sentence should also be compatible with various sceptical scenarios, such as that I am a brain in a vat being fed data from a computer simulation. In that case, the chair sentence would be true due to facts about the computer simulation, in much the way that "There are four chairs in this Minecraft house" is true. It would be very difficult to be open to a wide variety of fundamental physics stories about the chair sentence without being open to the sentence being true in virtue of facts about a computer simulation.
But now suppose that the same kind of thing is true for other sentences about physical things like tables, dogs, trees, human bodies, etc.: each of these sentences can be made true by a wide array of physical ontologies. Then it seems that nothing we say about physical things rules out sceptical scenarios: yes, I know I have two hands, but my having two hands could be grounded by facts about a computer simulation. At this point the meaningfulness of the sceptical question whether I know I am not a brain in a vat is breaking down. And with it, realism is breaking down.
In order for the sceptical question to make sense, we need the possibility of saying things that cannot simply be made true by a very wide variety of physical theories, since such things will also be made true by computer simulations. This gives us an interesting anti-reductionist argument. If the statement "I have two hands" is to be understood reductively (and I include non-Aristotelian functionalist views as reductive), then it could still be literally true in the brain-in-a-vat scenario. But if anti-reductionism about hands is true, then the statement wouldn't be true in the brain-in-a-vat scenario. And so I can deny that I am in that scenario simply by saying "I have two hands."
But maybe I am moving too fast here. Maybe "I have two hands" could be literally true in a brain-in-a-vat scenario. Suppose that the anti-reductionism consists of there being Aristotelian forms of hands (presumably accidental forms). But if, for all we know, the form of a hand can inform a bunch of particles, a fact about a vector or the region of a field, then the form of a hand can also inform an aspect of a computer simulation. And so, for all we know, I can literally and non-reductively have hands even if I am a brain in a vat. I am not sure, however, that I need to worry about this. What is important is form, not the precise material substrate. If physical reality is the memory of a giant computer but it isn't a mere simulation but is in fact informed by a multiplicity of substantial and accidental forms corresponding to people, trees, hands, hearts, etc., and these forms are real entities, then the scenario does not seem to me to be a sceptical scenario.