Some people are attracted to nihilism about proper parthood: no entity has proper parts. I used to be rather attracted to that myself, but I am now finding that a different thesis fits better with my intuitions: no entity is (fully) grounded. Or to put it positively: only fundamental entities exist.
This has some of the same consequences that nihilism about proper parthood would. For instance, on nihilism about proper parthood, there are no artifacts, since if there were any, they'd have proper parts. But on nihilism about ontological grounding, we can also argue that there are no artifacts, since the existence of an artifact would be grounded in social and physical facts. Moreover, nihilism about ontological grounding implies nihilism about mereological sum: for the existence of a mereological sum would be grounded in the existence of its proper parts. However, nihilism about ontological grounding is compatible with some things having parts--but they have to be things that go beyond their parts, things whose existence is not grounded in the existence and relations of their parts.