At times I am made uncomfortable by this objection to arguments for the existence of God: there feels like there is something fishy about inferring the existence of a being about which we know so very little. It may be that theism is the only reasonable explanation of the universe’s existence, but if we know so very little about that explanation, can the inference to the truth of that explanation be a genuine version of inference to best explanation?
Newton's disciple Samuel Clarke has a nice answer to this objection:
There is not so mean and contemptible a plant or animal, that does not confound the most enlarged understanding upon earth; nay, even the simplest and plainest of all inanimate beings have their essence or substance hidden from us in the deepest and most impenetrable obscurity.
In other words, all our ordinary day-to-day inferences are to things whose essence is hidden.
It may be thought that now that we know about DNA, we do know the essences of plants and animals. But even if that is true, which I am sceptical of, it doesn’t matter: for belief in plants and animals was quite reasonable even before our superior science. And even this day, our knowledge of the essences of the fundamental entities of physics (e.g., particles, fields, wavefunctions) is basically nil. All we know is some facts about the effects of these entities.
